Sildenafil Citrate

Category: Pharmaceutical Standards, Intermediates, Fine Chemicals

Synonyms:

• 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
• Piperazine, 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-, 2-hydroxy-1,2,3-propane­tricarboxylate (1:1)
• Sildenafil citrate (1:1) (USP)

Description:

Sildenafil Citrate is a well-known pharmaceutical compound primarily used for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It works by selectively inhibiting the enzyme cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cGMP in the smooth muscle cells lining blood vessels. By preventing cGMP breakdown, Sildenafil enhances blood flow to specific areas of the body, particularly the penis, aiding in the ability to achieve and maintain an erection.

Applications:

• Erectile Dysfunction: Increases blood flow to the penis during sexual stimulation, improving erectile response.
• Pulmonary Arterial Hypertension: Helps relax blood vessels in the lungs, reducing blood pressure and improving exercise capacity.
• Research & Development: Used as a reference standard or active pharmaceutical ingredient (API) in formulation and pharmacokinetic studies.